Issue 84, 2014

Continuous synthesis of artemisinin-derived medicines

Abstract

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

Graphical abstract: Continuous synthesis of artemisinin-derived medicines

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2014
Accepted
29 Aug 2014
First published
29 Aug 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 12652-12655

Author version available

Continuous synthesis of artemisinin-derived medicines

K. Gilmore, D. Kopetzki, J. W. Lee, Z. Horváth, D. T. McQuade, A. Seidel-Morgenstern and P. H. Seeberger, Chem. Commun., 2014, 50, 12652 DOI: 10.1039/C4CC05098C

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