Issue 73, 2014
From the journal:

Chemical Communications

Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides†

Feng Gao,ab   Byeong-Seon Kimb  and  Patrick J. Walsh*b  

* Corresponding authors

a Department of Medicinal Plants, Agronomy College, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang Region, Chengdu 611130, P. R. China

b Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA
E-mail: pwalsh@sas.upenn.edu

Abstract

An efficient room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl bromides is presented. The Pd(OAc)2/NiXantphos-based catalyst enables the introduction of various aryl and heteroaryl groups, via a deprotonative cross-coupling process (DCCP) in good to excellent yields (60–99%).

Graphical abstract: Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides

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Article information

DOI
https://doi.org/10.1039/C4CC05307A
Article type
Communication
Submitted
10 Jul 2014
Accepted
23 Jul 2014
First published
24 Jul 2014

Chem. Commun., 2014,50, 10661-10664

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Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides

F. Gao, B. Kim and P. J. Walsh, Chem. Commun., 2014, 50, 10661 DOI: 10.1039/C4CC05307A

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