The HGF/c-Met pathway is known to play a key role in cancer metastasis. CLN0003_SL1, a 50-mer DNA aptamer that binds to the c-Met protein, was found to inhibit HGF-induced c-Met activation. This aptamer could suppress cancer cell motility in vitro.
R. Ueki and S. Sando, Chem. Commun., 2014, 50, 13131 DOI: 10.1039/C4CC06016D
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