Issue 99, 2014

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

Abstract

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.

Graphical abstract: Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
02 Aug 2014
Accepted
28 Oct 2014
First published
28 Oct 2014

Chem. Commun., 2014,50, 15792-15795

Author version available

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

Y. Tian, X. Zhang, Y. Li, T. M. Shoup, X. Teng, D. R. Elmaleh, A. Moore and C. Ran, Chem. Commun., 2014, 50, 15792 DOI: 10.1039/C4CC06029F

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