Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

Liye Fu; Lingyao Li; Jun Wang; Kyle Knickelbein; Lin Zhang; Ian Milligan; Yi Xu; Kylie O'Hara; Lindsay Bitterman; Wenjun Du

doi:10.1039/C4CC06343K

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies†

Liye Fu,‡^a Lingyao Li,‡^a Jun Wang,‡^a Kyle Knickelbein,^b Lin Zhang,^b Ian Milligan,^a Yi Xu,^a Kylie O'Hara,^a Lindsay Bitterman^a and Wenjun Du*^a

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^a Department of Chemistry, Science of Advanced Materials, Central Michigan University, Mount Pleasant, MI 48858, USA
E-mail: du1w@cmich.edu

^b Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA

Abstract

The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF₃·OEt₂ as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

Chemical Communications

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies†

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