Issue 88, 2014

Multiplex detection of lung cancer cells at the single-molecule level

Abstract

We develop a simple and sensitive method for multiplex detection of lung cancer cells at the single-molecule level, with a detection limit of 15 cells per mL for A549 cells and 4 cells per mL for H23 cells, without the involvement of any sequence-based amplification. This method holds great potential for further application in early clinical diagnosis, especially for the detection of rare tumor cells.

Graphical abstract: Multiplex detection of lung cancer cells at the single-molecule level

Supplementary files

Article information

Article type
Communication
Submitted
17 Aug 2014
Accepted
11 Sep 2014
First published
11 Sep 2014

Chem. Commun., 2014,50, 13581-13584

Multiplex detection of lung cancer cells at the single-molecule level

J. Hu and C. Zhang, Chem. Commun., 2014, 50, 13581 DOI: 10.1039/C4CC06460G

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