Issue 96, 2014
From the journal:

Chemical Communications

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans†

Dhruv Thakar,ab   Elisa Migliorini,ab   Liliane Coche-Guerente,ab   Rabia Sadir,cde   Hugues Lortat-Jacob,cde   Didier Boturyn,ab   Olivier Renaudet,ab   Pierre Labbeab  and  Ralf P. Richter*abfg  

* Corresponding authors

a Université Grenoble Alpes, DCM, 38000 Grenoble, France

b CNRS, DCM, 38000 Grenoble, France

c Université Grenoble Alpes, Institut de Biologie Structurale (IBS), 38027 Grenoble, France

d CNRS, IBS, 38027 Grenoble, France

e CEA, DSV, IBS, 38027 Grenoble, France

f CIC biomaGUNE, Paseo Miramon 182, 20009 Donostia - San Sebastian, Spain
E-mail: rrichter@cicbiomagune.es
Tel: +34 943 00 53 29

g Max Planck Institute for Intelligent Systems, 70569 Stuttgart, Germany

Abstract

We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.

Graphical abstract: A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

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Article information

DOI
https://doi.org/10.1039/C4CC06905F
Article type
Communication
Submitted
01 Sep 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15148-15151

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A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

D. Thakar, E. Migliorini, L. Coche-Guerente, R. Sadir, H. Lortat-Jacob, D. Boturyn, O. Renaudet, P. Labbe and R. P. Richter, Chem. Commun., 2014, 50, 15148 DOI: 10.1039/C4CC06905F

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