The preparation of a polystyrene solid support decorated with a photolabile linker is described. The entire post-synthetic processing of RNA can be carried out in the solid phase in a minimum amount of time. The deprotected RNA is available for “on-support” hybridization and photolysis releases siRNA duplexes under mild, neutral conditions.
J. Lietard, M. R. Hassler, J. Fakhoury and M. J. Damha, Chem. Commun., 2014, 50, 15063 DOI: 10.1039/C4CC07153K
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