Issue 100, 2014
From the journal:

Chemical Communications

Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts†

Pu-Cha Yan,a   Jian-Hua Xie,bc   Xiang-Dong Zhang,a   Kang Chen,a   Yuan-Qiang Li,a   Qi-Lin Zhou*bc  and  Da-Qing Che*ac  

* Corresponding authors

a Zhejiang Jiuzhou Pharmaceutical Co., Ltd., 99 Waisha Road, Jiaojiang District, Taizhou City, Zhejiang Province, P. R. China
E-mail: dqche@zbjz.cn
Fax: +86-0571-87000702
Tel: +86-0571-87000701

b State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China
E-mail: qlzhou@nankai.edu.cn
Fax: +86-022-23500011
Tel: +86-022-23500011

c Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, P. R. China
Fax: +86-022-23500011
Tel: +86-022-23500011

Abstract

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

Graphical abstract: Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

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Article information

DOI
https://doi.org/10.1039/C4CC07643E
Article type
Communication
Submitted
27 Sep 2014
Accepted
02 Nov 2014
First published
04 Nov 2014

Chem. Commun., 2014,50, 15987-15990

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Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

P. Yan, J. Xie, X. Zhang, K. Chen, Y. Li, Q. Zhou and D. Che, Chem. Commun., 2014, 50, 15987 DOI: 10.1039/C4CC07643E

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