A detailed structural study and Hirshfeld surface analysis of cabazitaxel in its anhydrous, hydrated and solvated forms have revealed that the three-dimensional architecture of the drug molecule is retained regardless of the crystalline environment. This prompted comparison with its taxane predecessors, suggesting key factors contributing to cabazitaxel's poor affinity to P-gp.
U. Baisch and L. Vella-Zarb, CrystEngComm, 2014, 16, 10161 DOI: 10.1039/C4CE01279H
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