Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P.-L. Lam; G.-L. Lu; K.-M. Hon; K.-W. Lee; C.-L. Ho; X. Wang; J. C.-O. Tang; K.-H. Lam; R. S.-M. Wong; S. H.-L. Kok; Z.-X. Bian; H. Li; K. K.-H. Lee; R. Gambari; C.-H. Chui; W.-Y. Wong

doi:10.1039/C3DT52879K

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus†

P.-L. Lam,^a G.-L. Lu,^bc K.-M. Hon,^b K.-W. Lee,^b C.-L. Ho,^b X. Wang,^b J. C.-O. Tang,^a K.-H. Lam,^a R. S.-M. Wong,^d S. H.-L. Kok,^e Z.-X. Bian,^f H. Li,*^g K. K.-H. Lee,*^e R. Gambari,*^h C.-H. Chui*^f and W.-Y. Wong*^bi

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China

^b Institute of Molecular Functional Materials, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Hong Kong, P.R. China
E-mail: rwywong@hkbu.edu.hk
Fax: +852-3411 7348
Tel: +852-3411 7074

^c Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand

^d Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, P.R. China

^e School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, P.R. China
E-mail: kaholee@cuhk.edu.hk
Fax: +852-2603 5139
Tel: +852-3943 6785

^f Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, P.R. China
E-mail: chchui@hkbu.edu.hk
Fax: +852-2637 5396
Tel: +852-2632 1500

^g College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, P.R. China
E-mail: lihuamuc@gmail.com

^h Centre of Biotechnology, Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
E-mail: gam@unife.it
Fax: +39-532-202723
Tel: +39-532-974443

ⁱ Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P.R. China

Abstract

A series of ruthenium(II) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C₁, Ru-C₆, Ru-C₇ and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C₇ complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL⁻¹) and minimum bactericidal concentration (MBC, 25 μg mL⁻¹) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL⁻¹ and MBC = 100 μg mL⁻¹). The Ru-C₇ complex possessed much stronger antibacterial effects than the Ru-C₆ complex (MIC, 25 μg mL⁻¹, MBC, >100 μg mL⁻¹). Both Ru-C₆ and Ru-C₇ complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Dalton Transactions

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Social activity

Search articles by author

Spotlight

Advertisements