Issue 19, 2014
From the journal:

Dalton Transactions

Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation†

Qiang Xie,‡ab   Shenggui Liu,‡ac   Xiaoling Li,‡a   Qiong Wu,a   Zuandi Luo,a   Xiaoyan Fu,a   Wenqiang Cao,a   Guoqiang Lan,a   Dan Li,*d   Wenjie Zhenga  and  Tianfeng Chen*a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou 510632, China
E-mail: tchentf@jnu.edu.cn

b Wu Jing Zong Dui Hospital of Guangdong Province, Guangzhou, China

c Department of Chemistry Science and Technology, Zhanjiang Normal University, Zhanjiang 524048, P.R. China

d Department of Chemistry, Shantou University, Guangdong 515063, China
E-mail: dli@stu.edu.cn

Abstract

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

Graphical abstract: Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

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Article information

DOI
https://doi.org/10.1039/C4DT00198B
Article type
Communication
Submitted
20 Jan 2014
Accepted
27 Feb 2014
First published
03 Mar 2014

Dalton Trans., 2014,43, 6973-6976

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Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

Q. Xie, S. Liu, X. Li, Q. Wu, Z. Luo, X. Fu, W. Cao, G. Lan, D. Li, W. Zheng and T. Chen, Dalton Trans., 2014, 43, 6973 DOI: 10.1039/C4DT00198B

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