Issue 1, 2014

N-Chlorosuccinimide-promoted synthesis of thiophosphates from thiols and phosphonates under mild conditions

Abstract

A very simple N-chlorosuccinimide-promoted synthesis of thiophosphates through the coupling of thiols and phosphonates is reported. Notably, the reactions were carried out in the absence of a base. Functional groups including fluoro, bromo and trifluoromethyl are all tolerated by the reaction conditions employed. Both aryl and alkyl thiols are coupled smoothly with a broad spectrum of phosphonates to afford the corresponding thiophosphates in good to excellent yields.

Graphical abstract: N-Chlorosuccinimide-promoted synthesis of thiophosphates from thiols and phosphonates under mild conditions

Supplementary files

Article information

Article type
Paper
Submitted
04 Sep 2013
Accepted
26 Oct 2013
First published
28 Oct 2013

Green Chem., 2014,16, 357-364

N-Chlorosuccinimide-promoted synthesis of thiophosphates from thiols and phosphonates under mild conditions

Y. Liu and C. Lee, Green Chem., 2014, 16, 357 DOI: 10.1039/C3GC41839A

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