Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis

Abstract

A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H₂O₂) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.