Issue 20, 2014
From the journal:

Lab on a Chip

Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG–PLGA nanoparticles†

Kyoung-Ik Min,a   Do Jin Im,b   Hyune-Jea Leea  and  Dong-Pyo Kim*a  

* Corresponding authors

a Center of Applied Microfluidic Chemistry (CAMC), Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
E-mail: dpkim@postech.ac.kr

b Department of Chemical Engineering, Pukyong National University, Busan, Republic of Korea

Abstract

We present a pressure-tolerant 3D parallel polyimide (PI) film microreactor operating at up to ~160 bars with direct 3D flow focusing geometry for mass production of PEG–PLGA nanoparticles in a ~101 gram-scale (g h−1).

Graphical abstract: Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG–PLGA nanoparticles

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Article information

DOI
https://doi.org/10.1039/C4LC00700J
Article type
Paper
Submitted
16 Jun 2014
Accepted
25 Jul 2014
First published
25 Jul 2014

Lab Chip, 2014,14, 3987-3992

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Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG–PLGA nanoparticles

K. Min, D. J. Im, H. Lee and D. Kim, Lab Chip, 2014, 14, 3987 DOI: 10.1039/C4LC00700J

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