Rh-catalyzed allylic C–F bond activation: the stereoselective synthesis of trisubstituted monofluoroalkenes and a mechanism study

Abstract

Rhodium-catalyzed allylic C–F bond activation via oxidative addition was found to be a promising approach for the conversion of allylic difluoro-homoallylic alcohols into trisubstituted monofluoroalkenes in good yields with excellent stereoselectivity. The mechanism study shows that C–F bond activation via oxidative addition is involved and PPh₃ is responsible for the excellent stereoselectivity.