The first synthetic attempt commencing from an eight-membered ring to approach the [5.3.1] bicyclic core of vinigrol has demonstrated the feasibility of using the conformational bias of the cyclooctane-ring system to realize highly diastereoselective reactions. The synthetic potential of the newly disclosed access to in/out isomerism may stimulate broader interests.
![Graphical abstract: A novel synthetic approach to the bicyclo[5.3.1]undecan-11-one framework of vinigrol](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4OB00046C&imageInfo.ImageIdentifier.Year=2014)
X. Wang, Y. Lu, J. Wang, X. Wang, H. Yao, G. Lin and B. Sun, Org. Biomol. Chem., 2014, 12, 3562 DOI: 10.1039/C4OB00046C
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