A domino addition–lactonization pathway has been applied to a dynamic covalent resolution protocol, leading to efficient oxathiazinanone formation as well as chiral discrimination. A new, double biocatalytic pathway has furthermore been proposed and evaluated where the initial product inhibition could be efficiently circumvented.
L. Hu, Y. Zhang and O. Ramström, Org. Biomol. Chem., 2014, 12, 3572 DOI: 10.1039/C4OB00365A
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