Issue 26, 2014

Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

Abstract

2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structure–activity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism.

Graphical abstract: Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

Supplementary files

Article information

Article type
Paper
Submitted
25 Mar 2014
Accepted
09 May 2014
First published
09 May 2014

Org. Biomol. Chem., 2014,12, 4723-4729

Author version available

Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

Y. Wang, X. Liu, E. Laurini, P. Posocco, F. Ziarelli, M. Fermeglia, F. Qu, S. Pricl, C. Zhang and L. Peng, Org. Biomol. Chem., 2014, 12, 4723 DOI: 10.1039/C4OB00630E

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