Issue 27, 2014

Iodine-catalyzed aromatization of tetrahydrocarbazoles and its utility in the synthesis of glycozoline and murrayafoline A: a combined experimental and computational investigation

Abstract

A new protocol for the aromatization of tetrahydrocarbazoles has been achieved using a catalytic amount of iodine, giving high yields. The role of iodine in the aromatization has been explained by DFT, and its wide scope is extended to the total synthesis of glycozoline and murrayafoline A. This method has proven to be tolerant of a broad range of functional groups.

Graphical abstract: Iodine-catalyzed aromatization of tetrahydrocarbazoles and its utility in the synthesis of glycozoline and murrayafoline A: a combined experimental and computational investigation

Supplementary files

Article information

Article type
Communication
Submitted
25 Mar 2014
Accepted
24 Apr 2014
First published
24 Apr 2014

Org. Biomol. Chem., 2014,12, 4832-4836

Author version available

Iodine-catalyzed aromatization of tetrahydrocarbazoles and its utility in the synthesis of glycozoline and murrayafoline A: a combined experimental and computational investigation

V. Humne, Y. Dangat, K. Vanka and P. Lokhande, Org. Biomol. Chem., 2014, 12, 4832 DOI: 10.1039/C4OB00635F

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