Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes

Abstract

A novel approach for the synthesis of tertiary propargylamines is achieved through a Cu(OAc)₂-catalyzed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes, where a combination of PBM and A³-coupling reactions is involved in this new multicomponent reaction.