We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen. 3-Methyleneisoindoline derivatives are prepared in high yields.
Y. Zhang, Q. Wang, H. Yu and Y. Huang, Org. Biomol. Chem., 2014, 12, 8844 DOI: 10.1039/C4OB01312C
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