Issue 42, 2014
From the journal:

Organic & Biomolecular Chemistry

Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C†

Yi Liu,ab   Xue Sun,ab   Xing Zhang,a   Jun Liu*a  and  Yuguo Du*ab  

* Corresponding authors

a State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
E-mail: duyuguo@rcees.ac.cn, junliu@rcees.ac.cn
Fax: +86-010-62923563

b School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented.

Graphical abstract: Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C

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Article information

DOI
https://doi.org/10.1039/C4OB01460J
Article type
Paper
Submitted
11 Jul 2014
Accepted
27 Aug 2014
First published
28 Aug 2014

Org. Biomol. Chem., 2014,12, 8453-8461

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Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C

Y. Liu, X. Sun, X. Zhang, J. Liu and Y. Du, Org. Biomol. Chem., 2014, 12, 8453 DOI: 10.1039/C4OB01460J

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