A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary–tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.
S. Cheng and S. Yu, Org. Biomol. Chem., 2014, 12, 8607 DOI: 10.1039/C4OB01646G
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