Issue 6, 2014
From the journal:

Polymer Chemistry

Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization†

Junqiang Zhao,‡ab   Jinjian Liu,‡c   Shangcong Han,b   Hongzhang Deng,b   Liandong Deng,b   Jianfeng Liu,c   Aimin Meng,c   Anjie Dongabd  and  Jianhua Zhang*b  

* Corresponding authors

a School of Materials Science and Engineering, Tianjin University, Tianjin, PR China

b Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and, Technology, Tianjin University, Tianjin, PR China
E-mail: jhuazhang@tju.edu.cn
Fax: +86 22 27890706
Tel: +86 22 27890706

c Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, PR China

d Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, PR China

Abstract

Polymeric nanoparticles assembled from the amphiphilic graft copolymer with cyclic benzylidene acetal-functionalized backbone and short poly(2-hydroxyethyl methacrylate) side chains can remain structurally stable at pH 7.4, but undergo stepwise disassembly in mildly acidic conditions due to the acid-triggered cleavage of the acetals, providing a promising nanocarrier for cancer therapy.

Graphical abstract: Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization

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Article information

DOI
https://doi.org/10.1039/C3PY01324C
Article type
Communication
Submitted
22 Sep 2013
Accepted
01 Dec 2013
First published
02 Dec 2013

Polym. Chem., 2014,5, 1852-1856

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Acid-induced disassemblable nanoparticles based on cyclic benzylidene acetal-functionalized graft copolymer via sequential RAFT and ATRP polymerization

J. Zhao, J. Liu, S. Han, H. Deng, L. Deng, J. Liu, A. Meng, A. Dong and J. Zhang, Polym. Chem., 2014, 5, 1852 DOI: 10.1039/C3PY01324C

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