Biocompatible and biodegradable supramolecular assemblies formed with cucurbit[8]uril as a smart platform for reduction-triggered release of doxorubicin

Abstract

A truly novel strategy for fabricating reducible supramolecular assemblies based on the host–guest interaction between cucurbit[8]uril (CB[8]) and methyl viologen (MV) is reported. The anticancer drug doxorubicin is loaded into the assemblies and a reducing agent Na₂S₂O₄ can be used to successfully trigger release of drugs because of the redox chemistry of MV.