Issue 1, 2014

Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

Abstract

Transmetalation is the rate-limiting step in Negishi coupling: in a live “Pd-catalyzed Negishi coupling of ArI with Ar′ZnX”, the transmetalation was assigned as the rate-limiting step through kinetic investigation. Quantitative measurements of the transmetalation of ArZnX with [Ar–Pd–X] from this live Pd-catalyzed coupling reaction were obtained and the activation enthalpy is 11.3 kcal mol−1.

Graphical abstract: Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

Supplementary files

Article information

Article type
Research Article
Submitted
26 Oct 2013
Accepted
25 Nov 2013
First published
19 Dec 2013

Org. Chem. Front., 2014,1, 50-53

Transmetalation of Ar1ZnX with [Ar2–Pd–X] is the rate-limiting step: kinetic insights from a live Pd-catalyzed Negishi coupling

J. Li, L. Jin, C. Liu and A. Lei, Org. Chem. Front., 2014, 1, 50 DOI: 10.1039/C3QO00021D

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