We have discovered that bromine electrophile and carboxylate nucleophile can be added to conjugated enynes intermolecularly in a 1,4-fashion with high diastereoselectivity. Highly functionalized bromoallenes with an adjacent stereogenic centre were prepared from readily available conjugated 1,3-enynes.
H. Wang, W. Zhang, C. M. Schienebeck, S. R. Bennett and W. Tang, Org. Chem. Front., 2014, 1, 386 DOI: 10.1039/C3QO00088E
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