Issue 5, 2014

Palladium-catalyzed 1,4-addition of secondary alkylphenylphosphines to α,β-unsaturated carbonyl compounds for the synthesis of phosphorus- and carbon-stereogenic compounds

Abstract

Highly stereoselective 1,4-addition of alkylphenylphosphines to α,β-unsaturated carbonyl compounds catalyzed by PCP or NCN pincer–Pd complexes is described to synthesize chiral phosphorus compounds bearing both P- and C-stereogenic centers with good to excellent enantioselectivity (up to 99.6% ee).

Graphical abstract: Palladium-catalyzed 1,4-addition of secondary alkylphenylphosphines to α,β-unsaturated carbonyl compounds for the synthesis of phosphorus- and carbon-stereogenic compounds

Supplementary files

Article information

Article type
Research Article
Submitted
16 Jan 2014
Accepted
18 Apr 2014
First published
21 Apr 2014

Org. Chem. Front., 2014,1, 541-545

Author version available

Palladium-catalyzed 1,4-addition of secondary alkylphenylphosphines to α,β-unsaturated carbonyl compounds for the synthesis of phosphorus- and carbon-stereogenic compounds

C. Li, Q. Bian, S. Xu and W. Duan, Org. Chem. Front., 2014, 1, 541 DOI: 10.1039/C4QO00017J

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