Issue 10, 2014
From the journal:

Organic Chemistry Frontiers

Cu-mediated C–H cyanation of arenes using N,N-dimethylformamide (DMF) as the “CN” source†

Yuepeng Yan,a   Yizhi Yuana  and  Ning Jiao*ab  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China
E-mail: jiaoning@bjmu.edu.cn
Fax: (+86)-010-8280-5297

b State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

This paper describes the direct C–H bond cyanation of 2-phenylpyridines employing N,N-dimethylformamide (DMF) as both the reagent and solvent. DMF provides both the C and N units in the generated “CN” group in this cyanation transformation. This reaction gives a novel protocol with high atom economy to extend the application of DMF and provides an alternative approach to aryl nitriles.

Graphical abstract: Cu-mediated C–H cyanation of arenes using N,N-dimethylformamide (DMF) as the “CN” source

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Article information

DOI
https://doi.org/10.1039/C4QO00205A
Article type
Research Article
Submitted
22 Jul 2014
Accepted
17 Sep 2014
First published
18 Sep 2014

Org. Chem. Front., 2014,1, 1176-1179

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Cu-mediated C–H cyanation of arenes using N,N-dimethylformamide (DMF) as the “CN” source

Y. Yan, Y. Yuan and N. Jiao, Org. Chem. Front., 2014, 1, 1176 DOI: 10.1039/C4QO00205A

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