Issue 1, 2014
From the journal:

RSC Advances

Catalyst-free synthesis of benzofuran-fused pyrido[4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions†

Bo Li,ab   Zhizhou Yue,a   Haoyue Xiang,b   Linlin Lv,a   Shanshan Song,b   Zehong Miao*b  and  Chunhao Yang*b  

* Corresponding authors

a Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, 205 Luo Shi Road, Wuhan, Hubei, P.R. China

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, P.R. China
E-mail: zhmiao@simm.ac.cn, chyang@simm.ac.cn
Fax: +86-21-50806770
Tel: +86-21-50806770

Abstract

A rapid, one-pot, catalyst-free approach to novel benzofuran-fused pyrido[4,3-d]pyrimidines with good antitumor activities via a cascade SNAr/cyclization/condensation reaction through 2-(2-hydroxyphenyl)acetonitriles and 4,6-dichloropyrimidine-5-carbaldehyde was developed.

Graphical abstract: Catalyst-free synthesis of benzofuran-fused pyrido[4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3RA44828B
Article type
Paper
Submitted
02 Sep 2013
Accepted
06 Nov 2013
First published
07 Nov 2013

RSC Adv., 2014,4, 358-364

Permissions

Request permissions

Catalyst-free synthesis of benzofuran-fused pyrido[4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions

B. Li, Z. Yue, H. Xiang, L. Lv, S. Song, Z. Miao and C. Yang, RSC Adv., 2014, 4, 358 DOI: 10.1039/C3RA44828B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements