Issue 10, 2014
From the journal:

RSC Advances

Palladium-catalyzed annulation of internal alkynes in aqueous medium†

Wei Jie Ang,a   Chih-Hsuan Tai,b   Lee-Chiang Lo*b  and  Yulin Lam*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmlamyl@nus.edu.sg
Fax: +65-67791691
Tel: +65-65162688

b Department of Chemistry, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei 106, Taiwan
E-mail: lclo@ntu.edu.tw
Fax: +886-233668670
Tel: +886-233661669

Abstract

To facilitate precatalyst recovery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a very efficient and versatile precatalyst for carbo- and heteroannulation of internal alkynes with functionalized aryl halides in aqueous medium. A uniform reaction condition for these annulation reactions was also developed.

Graphical abstract: Palladium-catalyzed annulation of internal alkynes in aqueous medium

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Article information

DOI
https://doi.org/10.1039/C3RA46010J
Article type
Paper
Submitted
22 Oct 2013
Accepted
02 Dec 2013
First published
02 Dec 2013

RSC Adv., 2014,4, 4921-4929

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Palladium-catalyzed annulation of internal alkynes in aqueous medium

W. J. Ang, C. Tai, L. Lo and Y. Lam, RSC Adv., 2014, 4, 4921 DOI: 10.1039/C3RA46010J

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