A simple method is presented that optimizes the STD NMR Gaussian pulse to deliver significant increases in STD amplification factors with minimal perturbation of the ligand. This approach is practically demonstrated using the wheat-germ agglutinin/N-acetyl-D-glucosamine protein–ligand system.
N. B. Ley, M. L. Rowe, R. A. Williamson and M. J. Howard, RSC Adv., 2014, 4, 7347 DOI: 10.1039/C3RA46246C
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