Highly selective direct reductive amidation of nitroarenes with carboxylic acids using cobalt(ii) phthalocyanine/PMHS

Abstract

Cobalt phthalocyanine has been employed for highly chemoselective direct reductive amidation of nitroarenes with non-activated carboxylic acids using polymethylhydrosiloxane as an inexpensive, stable and environmentally benign reducing agent. A large range of functional groups such as amide, ester, nitrile, halogen, lactone, hydroxy, alkene and heterocycles were well tolerated.