Toxicity of high glycolic poly(dl-lactic-co-glycolic acid) stabilized ruthenium nanoparticles against human promyelocytic leukemia cells

Abstract

High glycolic poly-(lactic-co-glycolic acid) stabilized ruthenium nanoparticles were toxic towards human promyelocytic leukemia cells (HL60) and the mode of cell death was by apoptosis and in contrast it was not toxic towards blood lymphocytes. There was a significant increase in the oxidative stress within these cells and the toxicity of nanoparticles towards HL 60 cells could be attributed to the TGF β mediated signal transduction. This study indicated that such polymer stabilized ruthenium nanoparticles could be used as a selective anticancer agent.