A highly sensitive and selective turn-on fluorescent chemodosimeter for Cu2+ based on BODIPY and its application in bioimaging

Jia-Hai Ye; Jing Xu; Huachao Chen; Yang Bai; Wenchao Zhang; Weijiang He

doi:10.1039/C3RA47157H

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A highly sensitive and selective turn-on fluorescent chemodosimeter for Cu²⁺ based on BODIPY and its application in bioimaging†

Jia-Hai Ye,*^a Jing Xu,^a Huachao Chen,^b Yang Bai,^b Wenchao Zhang^a and Weijiang He*^b

Author affiliations

* Corresponding authors

^a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, P. R. China
E-mail: yejiahai@njust.edu.cn
Fax: +86 25 8431 5857
Tel: +86 25 8430 3116

^b State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: heweij69@nju.edu.cn
Fax: +86 25 8331 4502
Tel: +86 25 8359 7066

Abstract

A BODIPY-based turn-on fluorescent probe 1 has been designed and synthesized for fluorescence detection of Cu²⁺ in aqueous media and imaging in living cells. The C [double bond, length as m-dash] N bonds are selectively hydrolyzed by the reaction with Cu²⁺ to generate formyl-BODIPY. The favorable features of probe 1 towards Cu²⁺ include significant fluorescence enhancement (over 290-fold), high selectivity and low detection limit (0.1 μM).

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Article information

DOI: https://doi.org/10.1039/C3RA47157H
Article type: Communication
Submitted: 29 Nov 2013
Accepted: 02 Jan 2014
First published: 06 Jan 2014

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RSC Adv., 2014,4, 6691-6695

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A highly sensitive and selective turn-on fluorescent chemodosimeter for Cu²⁺ based on BODIPY and its application in bioimaging

J. Ye, J. Xu, H. Chen, Y. Bai, W. Zhang and W. He, RSC Adv., 2014, 4, 6691 DOI: 10.1039/C3RA47157H

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