Issue 17, 2014
From the journal:

RSC Advances

Oxone-mediated oxidative carbon-heteroatom bond cleavage: synthesis of benzoxazinones from benzoxazoles with α-oxocarboxylic acids†

Hua Wang,a   Hua Yang,a   Yiping Lib  and  Xin-Hua Duan*a  

* Corresponding authors

a Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China
E-mail: duanxh@mail.xjtu.edu.cn

b Department of Pharmacy, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China

Abstract

A metal-free oxidative cleavage of benzoxazoles using Oxone as an oxidant has been developed. The in situ formed o-aminophenol has been proved to react successfully with α-oxocarboxylic acids affording the benzoxazinones in moderate to good yields.

Graphical abstract: Oxone-mediated oxidative carbon-heteroatom bond cleavage: synthesis of benzoxazinones from benzoxazoles with α-oxocarboxylic acids

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Article information

DOI
https://doi.org/10.1039/C3RA47660J
Article type
Communication
Submitted
16 Dec 2013
Accepted
17 Jan 2014
First published
20 Jan 2014

RSC Adv., 2014,4, 8720-8722

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Oxone-mediated oxidative carbon-heteroatom bond cleavage: synthesis of benzoxazinones from benzoxazoles with α-oxocarboxylic acids

H. Wang, H. Yang, Y. Li and X. Duan, RSC Adv., 2014, 4, 8720 DOI: 10.1039/C3RA47660J

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