Issue 26, 2014
From the journal:

RSC Advances

Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells†

Kazuhito Tanabe,*a   Yuichiro Ando,a   Daiki Hara,a   Takeo Itoa  and  Sei-ichi Nishimotoa  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: tanabeka@scl.kyoto-u.ac.jp
Fax: +81-75-383-2504
Tel: +81-75-383-2505

Abstract

We prepared DNA amphiphiles with modified phosphate units, and characterized their properties of aggregate formation. The oligodeoxynucleotides with five consecutive hydrophobic phosphate groups aggregated to encapsulate hydrophobic nile red dye, and the resulting aggregates efficiently delivered the hydrophobic nile red as a virtual drug into living cells.

Graphical abstract: Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells

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Article information

DOI
https://doi.org/10.1039/C3RA47662F
Article type
Communication
Submitted
16 Dec 2013
Accepted
19 Feb 2014
First published
03 Mar 2014

RSC Adv., 2014,4, 13367-13370

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Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells

K. Tanabe, Y. Ando, D. Hara, T. Ito and S. Nishimoto, RSC Adv., 2014, 4, 13367 DOI: 10.1039/C3RA47662F

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