Issue 18, 2014
From the journal:

RSC Advances

Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers†

Amrei Deutsch,a   Herbert Glas,b   Anja Hoffmann-Röder*a  and  Carl Deutsch*b  

* Corresponding authors

a Center For Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-Universitaet, Butenandtstr. 5–13, 81377 Munich, Germany
E-mail: Anja.Hoffmann-Roeder@cup.lmu.de
Fax: +49 89 2180 77914
Tel: +49 89 2180 77913

b Medicinal Chemistry, Merck, Frankfurter Strasse 250, 64293 Darmstadt, Germany
E-mail: Carl.Deutsch@merckgroup.com
Tel: +49 6151 72 2500

Abstract

The synthesis of a variety of α-branched trifluoroethyl amines was achieved by reaction of N-aryl hemiaminal ethers with organomagnesium reagents.

Graphical abstract: Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers

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DOI
https://doi.org/10.1039/C3RA47708H
Article type
Communication
Submitted
17 Dec 2013
Accepted
22 Jan 2014
First published
23 Jan 2014
This article is Open Access
Creative Commons BY license

RSC Adv., 2014,4, 9288-9291

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Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers

A. Deutsch, H. Glas, A. Hoffmann-Röder and C. Deutsch, RSC Adv., 2014, 4, 9288 DOI: 10.1039/C3RA47708H

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