A transition metal-free route to 3-halopiperidines and 2-halomethylpiperidines was described. In the presence of iodine, potassium persulfate and a suitable halogen source, intramolecular haloamination of 4-penten-1-amines and 5-hexen-1-amines proceeded readily, leading to the corresponding substituted piperidines in good isolated yields.
W. Li, G. Liu, B. Cui, L. Zhang, T. Li, L. Li, L. Duan and Y. Li, RSC Adv., 2014, 4, 13509 DOI: 10.1039/C4RA00383G
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