Issue 41, 2014
From the journal:

RSC Advances

Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

Hanen Saggadi,ab   Denis Luart,a   Nicolas Thiebault,a   Isabelle Polaert,b   Lionel Estelb  and  C. Len*ac  

* Corresponding authors

a Transformations Intégrées de la Matière Renouvelable, EA 4297, UTC-ESCOM, Centre de Recherche de Royallieu, BP 20529, F-60200 Compiègne, France
E-mail: christophe.len@utc.fr
Fax: +33 0 344971591
Tel: +33 0 344238828

b Laboratoire de Sécurité des Procédés Chimiques – EA 4704 INSA Rouen, Avenue de l'Université, F-76801 Saint-Etienne-du-Rouvray Cedex, France

c Department of Chemistry, University of Hull, Hull, England

Abstract

An efficient “green” modified Skraup reaction in neat water was developed using inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions. Starting from aniline derivatives, various quinolines were obtained in 10–66% yields. The use of nitroaniline led to the corresponding phenanthrolines in 15–52% yields, respectively.

Graphical abstract: Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

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Article information

DOI
https://doi.org/10.1039/C4RA00758A
Article type
Communication
Submitted
25 Jan 2014
Accepted
23 Apr 2014
First published
29 Apr 2014

RSC Adv., 2014,4, 21456-21464

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Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

H. Saggadi, D. Luart, N. Thiebault, I. Polaert, L. Estel and C. Len, RSC Adv., 2014, 4, 21456 DOI: 10.1039/C4RA00758A

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