A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.
S. P. Chavan, K. P. Pawar and S. Garai, RSC Adv., 2014, 4, 14468 DOI: 10.1039/C4RA00840E
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