Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization†
Abstract
An easy metal free access to the synthesis of medicinally promising 2-oxindole derivatives via a tandem enamine formation – Michael addition – regiospecific intramolecular cyclization – aromatization sequence promoted by trifluoroacetic acid has been described. This three component reaction is regiospecific with good yield and satisfactory atom economy.