Issue 36, 2014

Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization

Abstract

An easy metal free access to the synthesis of medicinally promising 2-oxindole derivatives via a tandem enamine formation – Michael addition – regiospecific intramolecular cyclization – aromatization sequence promoted by trifluoroacetic acid has been described. This three component reaction is regiospecific with good yield and satisfactory atom economy.

Graphical abstract: Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization

Supplementary files

Article information

Article type
Paper
Submitted
10 Mar 2014
Accepted
07 Apr 2014
First published
09 Apr 2014

RSC Adv., 2014,4, 18549-18557

Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization

M. Boominathan, M. Nagaraj, S. Muthusubramanian and N. Bhuvanesh, RSC Adv., 2014, 4, 18549 DOI: 10.1039/C4RA02091J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements