Iron-catalyzed efficient intermolecular amination of C(sp3)–H bonds with bromamine-T as nitrene source

Haiyu Wang; Yuxi Li; Zhiming Wang; Jun Lou; Yuling Xiao; Guofu Qiu; Xianming Hu; Hans-Josef Altenbach; Peng Liu

doi:10.1039/C4RA02240H

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Iron-catalyzed efficient intermolecular amination of C(sp³)–H bonds with bromamine-T as nitrene source†

Haiyu Wang,^a Yuxi Li,^a Zhiming Wang,^a Jun Lou,^a Yuling Xiao,^a Guofu Qiu,^a Xianming Hu,^a Hans-Josef Altenbach^b and Peng Liu*^a

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* Corresponding authors

^a State Key Laboratory of Virology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China
E-mail: liupengwhu@whu.edu.cn
Fax: +86-027-6875-9850
Tel: +86-027-6875-9100

^b Bergische Universität Wuppertal, FB 9, Organische Chemie, Gauss-Str. 20, 42097 Wuppertal, Germany

Abstract

[Fe(N4Py)(CH₃CN)](ClO₄)₂ can efficiently catalyze intermolecular nitrene insertion of sp³ C–H bonds with bromamine-T as the nitrene source, forming the desired tosylprotected amines with NaBr as the by-product.

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Article information

DOI: https://doi.org/10.1039/C4RA02240H
Article type: Communication
Submitted: 19 Mar 2014
Accepted: 29 May 2014
First published: 29 May 2014

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RSC Adv., 2014,4, 25287-25290

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Iron-catalyzed efficient intermolecular amination of C(sp³)–H bonds with bromamine-T as nitrene source

H. Wang, Y. Li, Z. Wang, J. Lou, Y. Xiao, G. Qiu, X. Hu, H. Altenbach and P. Liu, RSC Adv., 2014, 4, 25287 DOI: 10.1039/C4RA02240H

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