Issue 36, 2014
From the journal:

RSC Advances

Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor†

B. Patel,a   G. Saviolaki,a   C. Ayats,a   M. A. E. Garcia,a   T. Kapadiaa  and  S. T. Hilton*a  

* Corresponding authors

a UCL School of Pharmacy, 29-39 Brunswick Square, London, UK
E-mail: s.hilton@ucl.ac.uk
Fax: +44 (0)2077535964
Tel: +44 (0)2077535804

Abstract

A novel common precursor approach towards both tricyclic and spirocyclic heterocycles is described. Cyclisations are based on thiyl radical/isocyanide methodology and avoid the use of tin.

Graphical abstract: Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor

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Article information

DOI
https://doi.org/10.1039/C4RA02420F
Article type
Communication
Submitted
11 Mar 2014
Accepted
01 Apr 2014
First published
02 Apr 2014

RSC Adv., 2014,4, 18930-18932

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Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor

B. Patel, G. Saviolaki, C. Ayats, M. A. E. Garcia, T. Kapadia and S. T. Hilton, RSC Adv., 2014, 4, 18930 DOI: 10.1039/C4RA02420F

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