Issue 94, 2014
From the journal:

RSC Advances

Synthesis of 4-methyl-2,3-disubstituted quinoline scaffolds via environmentally benign Fe(iii) catalysed sequential condensation, cyclization and aromatization of 1,3-diketone and 2-ethynylaniline†

Mahalingam Sivaramana  and  Paramasivan T. Perumal*a  

* Corresponding authors

a Organic Chemistry Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamilnadu, India
E-mail: ptperumal@gmail.com
Fax: +91-044-24911589

Abstract

Environmentally benign Fe(III)-catalysed sequential condensation, cyclization and aromatization of 1,3-diketone and 2-ethynylaniline derivatives to the substituted quinoline scaffolds with good to excellent yield in shorter reaction time is described.

Graphical abstract: Synthesis of 4-methyl-2,3-disubstituted quinoline scaffolds via environmentally benign Fe(iii) catalysed sequential condensation, cyclization and aromatization of 1,3-diketone and 2-ethynylaniline

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Article information

DOI
https://doi.org/10.1039/C4RA03666B
Article type
Paper
Submitted
22 Apr 2014
Accepted
26 Sep 2014
First published
29 Sep 2014

RSC Adv., 2014,4, 52060-52066

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Synthesis of 4-methyl-2,3-disubstituted quinoline scaffolds via environmentally benign Fe(III) catalysed sequential condensation, cyclization and aromatization of 1,3-diketone and 2-ethynylaniline

M. Sivaraman and P. T. Perumal, RSC Adv., 2014, 4, 52060 DOI: 10.1039/C4RA03666B

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