Issue 57, 2014
From the journal:

RSC Advances

Peptidomimetic organocatalysts: efficient Michael addition of ketones onto nitroolefins with very low catalyst loading†

Srivari Chandrasekhar,*a   Chintakunta Praveen Kumar,a   Togapur Pavan Kumar,a   Kothapalli Haribabu,a   Bharatam Jagadeesh,*b   Jerripothula K. Lakshmib  and  Prathama S. Mainkar*a  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, India
E-mail: srivaric@iict.res.in
Fax: +91-40-27160512

b Centre for NMR and Structural Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, India
E-mail: bj@iict.res.in
Fax: +91-40-27160512

Abstract

The syntheses of two novel peptidomimetic triazole-based organocatalysts that work for the asymmetric conjugate addition of cyclohexanone to nitroolefins are described. The catalysts worked with very low loading (0.5 mol%) in the absence of any additives to provide high diastereo- and enantio-selectivities.

Graphical abstract: Peptidomimetic organocatalysts: efficient Michael addition of ketones onto nitroolefins with very low catalyst loading

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Article information

DOI
https://doi.org/10.1039/C4RA04165H
Article type
Communication
Submitted
06 May 2014
Accepted
19 Jun 2014
First published
19 Jun 2014

RSC Adv., 2014,4, 30325-30331

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Peptidomimetic organocatalysts: efficient Michael addition of ketones onto nitroolefins with very low catalyst loading

S. Chandrasekhar, C. P. Kumar, T. P. Kumar, K. Haribabu, B. Jagadeesh, J. K. Lakshmi and P. S. Mainkar, RSC Adv., 2014, 4, 30325 DOI: 10.1039/C4RA04165H

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