I2-promoted cross-dehydrogenative coupling of α-carbonyl aldehydes with alcohols for the synthesis of α-ketoesters†
Abstract
A facile and efficient method for the synthesis of α-ketoesters from alcohols and α-carbonyl aldehydes has been developed at room temperature under metal-free conditions for the first time. Various alcohols and α-carbonyl aldehydes could participate in this reaction to afford the desired products in excellent yields.