Pd-catalyzed oxidative C–H arylation of heterocycle embedded thiophene/furan with aryl boronic acid/ester†
Abstract
Palladium catalyzed oxidative C–H arylation of heterocycle embedded thiophenes with aryl boronic acids is described. This method is found to display high C5-selectivity and thus enabled rapid access to 2,5-disubstituted thiophenes. Furan analogs also exhibited a similar selectivity.