Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized.
S. K. Rai, S. Khanam, R. S. Khanna and A. K. Tewari, RSC Adv., 2014, 4, 44141 DOI: 10.1039/C4RA06619G
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